Ucoceko oluPhezulu 540737-29-9 Tofacitinib citrate yeJAK Pathway Inhibitor

Inkcazelo emfutshane:

Ubunyulu:≧99.0%

Umgangatho Womgangatho:Umgangatho woShishino okanye njengoko kufuneka

Umthamo:35Kgs/ngenyanga

Beka ubomi kwishelufa:Iminyaka emithathu

Isicelo:Nyanga i-rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis kunye ne-ulcerative colitis

Iqela eliluncedo:Iqela lokuthengisa impahla ngaphandle elinamava kunye noqeqesho lobungcali kumzi-mveliso

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Iithegi zeMveliso

Imvelisoigama	I-Tofacitinib Citrate
Izithethantonye	(3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2-hydroxy-1,2,3 -propanetricarboxylate;CP 690500-10;CP 690550-10;(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-beta-oxo-1-piperidinepropanenitrile 2-Hydroxy-1,2,3-propanetricarboxylate
Inombolo yeCAS.	540737-29-9
Imbonakalo	Kumhlophe ukuya kumgubo omhlophe
Ifomula yeemolekyuli	C₁₆H₂₀N₆OC₆H₈O₇
Ubunzima beMolekyuli	504.50
Isicelo	Ibakala leyeza okanye injongo yophando
Ukupakisha	Ngokwesicelo sakho
Ugcino	Londoloza kwizikhongozeli eziqinile, ezikwaziyo ukumelana nokukhanya kwindawo epholileyo

I-Tofacitinib Citrate (CAS #540737-29-9)
IZINTO	IMIGANGATHO	IZIPHUMO
Imbonakalo	Kumhlophe ukuya kumgubo omhlophe	Umgubo omhlophe
Ukuchongwa	I-HPLC;I-IR;HNMR	Iyahambelana
Ukunyibilika	I-Soluble kwi-DMSO kwi-100mg/ml, i-soluble kakhulu kwi-ethanol, i-soluble kancinci emanzini njl.	Iyahambelana
Ilahleko ekomisweni	≤0.5%	0.12%
Intsalela ekutshisweni	≤0.1%	0.05%
Iintsimbi ezinzima	≤10ppm	Iyahambelana
Izinto ezinxulumeneyo	I-Diasteomer (RS+SR) ≤0.1% Ukungcola okukunye ≤0.15% Ubumdaka bubonke ≤1.0%	0.05% 0.14% 0.18%
Enantiomorphism Isomers	≤0.2%	Iyahambelana
Izinyibilikisi ezishiyekileyo	I-Ethanol ≤5000ppm IMethanol ≤3000ppm Toluene ≤890ppm	Iyahambelana
Umxholo weCitrate	36.2%~40%	37.8%
Ubunyulu	≥99.0%	99.38%
Isivavanyi	60.68% ~ 63.16% ye-Tofacitinib INN I-98% ~ 102% ye-Tofacitinib Citrate INN	62.04% 99.12%
Isiphelo: Iyahambelana

Ulwazi lweNkampani

√ Amava apheleleyo omaleko wolawulo kumzi-mveliso kunye namagcisa anezakhono abalandeli;
√ Umgangatho usoloko uyingqwalasela yethu ephezulu, inkqubo yeQC eQinisekileyo;
√ Iminyaka eli-11 yamava eqela lokuthengisa kumazwe angaphandle;
√ ilebhu yeR&D eZimeleyo;
√ Iindibano zocweyo zeGMP ezimbini ezityikityiweyo zexesha elide;
√ Imithombo etyebileyo yeefektri ezininzi ezingasebenziyo ukulungiselela iprojekthi elungelelanisiweyo;
√ Iqela elisebenzayo eliSebenzayo ngokuSebenzayo ngendlela engaguqukiyo.
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